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Introduction:The aim of the study was to determine the effects of plasminogen activator inhibitor type-1(PAI-1)on mesenchymal stem cell in LPS-induced acute lung injury.Methods: In vivo,wild type mice were randomly divided into 4 groups: PBS group,LPS group,human embryonic lung fibroblast cells(HELFs)group and human mesenchymal stem cells(MSCs)group(n=5 per group).