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Multidrug resistance (MDR) is a major barrier for chemotherapy of many cancers.Mdr-1 plays a key role in the development of MDR as extensively verified.However,the role of Raf-1 overexpression in the development of multidrug resistance in human squamous carcinoma (KBv200) cells remains largely unknown.The aim of this study was to investigate the correlation of Raf-1 overexpression with the development of multidrug resistance in KBv200 cells.Furthermore,we explored the reversal effect of Raf-1 siRNA transfection and Raf-l/Mdr-1 siRNAs co-transfection on the multidrug resistance of KBv200 cells and potential mechanism of reversing the multidrug resistance.