Polyubiquitin Linkage Profiles in Models of Proteolytic Stress Suggest Alzheimer Disease Etiology

来源 :第七届中国蛋白质组学大会暨第三届国际蛋白质组学论坛 | 被引量 : 0次 | 上传用户：sunuplee

【摘要】

：

PolyUb linkages modify and regulate the fate of substrates.We present a MS-based method to measure polyUb linkages directly from total lysate.Tissue specificity

【作者】

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Dammer Eric

【机构】

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EmoryUniversity

【出处】

：

第七届中国蛋白质组学大会暨第三届国际蛋白质组学论坛

【发表日期】

：

2011年4期

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PolyUb linkages modify and regulate the fate of substrates.We present a MS-based method to measure polyUb linkages directly from total lysate.Tissue specificity of linkages was examined in HEK293 cells and mice labeled by heavy stable isotopes (SILAC).

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Polyubiquitin Linkage Profiles in Models of Proteolytic Stress Suggest Alzheimer Disease Etiology

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