Conditional knockout of TFPI-1 in VSMCs accelerates atherosclerosis by enhancing AMOT/YAP/SLUG+CTGF

来源 :第十四次全国医学遗传学学术会议 | 被引量 : 0次 | 上传用户：rwsonny

【摘要】

：

　　Tissue factor pathway inhibitor-1 (TFPI-1) has multiple functions and is involved in atherosclerosis, but its precise role and molecular mechanism during th

【作者】

：

JiajunXiao[1]KaiyueJin[1]JipingWang[1]JingMa[1]LeiDiao[1]JinZhang[1]NanJiang[1]HuijunWang[2]GuoyingHuang[2]XinpingLuo[3]JianFei[4]ZhugangWang[4]XiaoYang[5]DuanMa[6]

【机构】

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Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Collaborative Innovation

【出处】

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第十四次全国医学遗传学学术会议

【发表日期】

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2015年期

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　　Tissue factor pathway inhibitor-1 (TFPI-1) has multiple functions and is involved in atherosclerosis, but its precise role and molecular mechanism during the development of atherosclerosis are not clear.To determine the effect and molecular mechanism of TFPI-1 deficiency in vascular smooth muscle cells (VSMCs) in atherosclerosis in the ApoE-/-mouse.

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Conditional knockout of TFPI-1 in VSMCs accelerates atherosclerosis by enhancing AMOT/YAP/SLUG+CTGF

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