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Parkinsons disease (PD) is an age-related neurodegenerative disease.Although its pathogenic mechanism is not understand,oxidative stress is believed to play a key role in this process.In order to clarify its influence on PD progress,we performed study in eight rhesus monkeys treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by intramuscular injection to develop a slow evolution of PD.