The Catalytic Triad are Essential for TSP50 to Perform Its Function in Cell Proliferation

来源 :中国细胞生物学学会全体会员代表大会暨第十二次学术大会 | 被引量 : 0次 | 上传用户：you0tmd1234

【摘要】

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【作者】

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Yu-Yin Li Yan-Xin Huang Ying Sun Li-Hua Zheng Guan-Nan Wang Yu-Xin Li Yong-Li Bao Zhen-Bo Song Lu-Guo Sun Ping Wu YuZhang Cong Fan Yin Wu Chun-Lei Yu

【机构】

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National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal Universit

【出处】

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中国细胞生物学学会全体会员代表大会暨第十二次学术大会

【发表日期】

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2011年3期

【关键词】

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Serine protease TSP50 mechanism cell proliferation NF-κB signaling tumor formati

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　　Testes-specific protease 50 (TSP50), a new threonine enzyme, shares similar aa sequence and enzymatic structure with many serine proteases and is proposed to be a potential oncogene.TSP50 is up-regulated in breast cancer epithelial cells, and ectopic expression of TSP50 in TSP50-deficient Chinese hamster ovary (CHO) cells markedly promoted cell proliferation.However, the mechanism(s) by which TSP50 exerts its growth promotion effects are not yet fully understood.

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The Catalytic Triad are Essential for TSP50 to Perform Its Function in Cell Proliferation

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