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Oxytetracycline was widely applied as the treament and additive in the feed to prevent poultry and humans from diseases.Due to the abuse of oxytetracycline,it has serious harm for both poultry and humans.In order to further study on its toxicity and harm of its residues through food toward humans,the study of its accumulative toxicity was in operation by hybird chickens.The results showed:①symptom before death:those chickens appeared poor in spirit and appetite,addicted to sleeping and even worse with death;②changs after anatomy:livers swelled seriously.