【摘 要】
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Large-conductance calcium-activated potassium channels(BK channels),widely expressed in various cells and tissues of mammals except myocardial cells,responding to two distinct physiological stimuli,i.
【机 构】
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Department of Chemistry,Shanghai University,Shanghai 200444
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Large-conductance calcium-activated potassium channels(BK channels),widely expressed in various cells and tissues of mammals except myocardial cells,responding to two distinct physiological stimuli,i.e.,changes in membrane voltage and in cytosolic Ca2+ concentration,and may serve as a negative feedback pathway to control ionic homeostasis and cell excitability.Agents that open these channels could have profound impacts on diseases such as acute stroke,epilepsy,asthma,and bladder overactivity.Preliminary research showed dehydroabietic acid(DHAA,1) derivatives had the potential biological activities in opening BK channels.Structure-activity relationship(SAR) studies have also revealed that the 4-carboxyl group was necessary for the activity as the BK channel opener and the substituents of C-7 were possibly essential for the activity.
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