Parkinsons disease(PD)is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra(SN)and the appearance of fibrillar aggregates of α-synuclein calle
Spinocerebellar ataxia type 3/Machado-Joseph disease(SCA3/MJD)is the most common subtypes of spinocerebellar ataxias in China,which belong to the polyglutamine diseases.