【摘 要】
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Background Many epidemiological studies indicated that prolonged high iodine intake would lead to an elevation of serum thyrotrophin (TSH) level, but the mechanism is elusive.Type 2 iodothyronine deio
【机 构】
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Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Labo
【出 处】
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中华医学会第十四次全国内分泌学学术会议
论文部分内容阅读
Background Many epidemiological studies indicated that prolonged high iodine intake would lead to an elevation of serum thyrotrophin (TSH) level, but the mechanism is elusive.Type 2 iodothyronine deiodinase (D2) plays a crucial role in regulation of hypothalamic-pituitary-thyroid axis (HPT axis).Our previous studies have observed that activity of pituitary D2 is suppressed in Wistar rats fed with high iodine, suggesting a role for D2 in the iodine-induced TSH increment.The aim of this study was to illuminate the effect of iodine on D2 ubiquitination and its potential mechanism.
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