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Neurodegenerative diseases are progressive neurological disorders with selective neuron loss in particular regions of brain, including frontotemporal lobar degeneration (FTLD),Alzheimers disease (AD), amyotrophic lateral sclerosis (ALS), Parkinsons disease (PD),and many others. Gene defects have been recognized as a prominent factor in the etiology and pathogenesis of neurodegenerative diseases.