Checkpoint kinase 1(Chk1)represents an attractive target for anticancer therapy and the development of small molecule Chk1 inhibitors has delivered new strategies for enhancement of traditional DNA-da
Microsomal prostaglandin E synthase-1(mPGES-1)is the terminal enzyme of the PGE2 production pathway.The inhibition of the mPGES-1 would result in reduced formation of PGE2,which is a main mediator of