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  5. Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes

Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes

来源 :2014年中国药学大会暨第十四届中国药师周 | 被引量 : 0次 | 上传用户：tony569257
【摘 要】
：
A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1α,GT1aα,and GQ1bα is described.It relies on chemical manipulation of
【作 者】
：
Xin Meng Wenlong Yao Jiansong Cheng Xu Zhang Lan Jin Hai Yu Xi Chen Hongzhi Cao Fengshan Wang 
【机 构】
：
National Glycoengineering Research Center,School of Pharmaceutical Science,Shandong University,Jinan
【出 处】
：
2014年中国药学大会暨第十四届中国药师周
【发表日期】
：
2014年6期
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　　A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1α,GT1aα,and GQ1bα is described.It relies on chemical manipulation of enzymatically generated trisaccharides as conformationally constrained acceptors for regioselective enzymatic α2-6-sialylation.This strategy provides a new route for easy access to disialyl tetrasaccharide epitopes and their derivatives.
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