CENPT与PFV相互作用的初探

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户:xushaowei20092009
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  泡沫病毒(foamy virus,FV)属于反转录病毒科泡沫病毒亚科,它在体外培养的细胞或组织中能引起强烈病变效应,但尚未有报道表明它能在天然宿主体内形成致病症状,仅潜伏感染并伴随宿主终身。原型泡沫病毒(prototypefoamy virus,PFV)作为唯一感染人类的泡沫病毒,已经发现数种宿主限制因子可以抑制PFV复制,但PFV感染对细胞基因表达的影响尚待全面深入研究。本实验室前期利用PFV感染人纤维肉瘤细胞,提取细胞RNA进行转录组测序,结果发现被感染细胞中有多种基因mRNA水平上调,其中CENPT(centromere protein T)的mRNA 水平上调最为显著。
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