Background: Fractional flow reserve (FFR) has become an increasingly important index when making decisions with respect to revascularization of coronary artery stenosis.However, the pressure guidewire used in obtaining FFR measurements is difficult to control and manipulate in certain complex coronary artery lesions, resulting in increased fluoroscopy time and contrast dye usage.This study examined a novel (NOV) technique for obtaining FFR measurements in hope of easing the difficulties associated with evaluating and treating complex coronary artery lesions.Methods: Fifty-six patients with complex coronary artery lesions were assigned to a conventional (CON) FFR technique group or a NOV FFR technique group.The NOV technique involved the use of a balloon and wire exchange within the coronary artery.The fluoroscopy time, contrast dye usage, and FFR-related complications were assessed after completing the FFR measurement procedure for each patient.Results: The median time required for fluoroscopy in the NOV technique group was significantly less than that in the CON technique group;additionally, lesser amounts of contrast dye were used in the NOV technique group (both P < 0.05).The NOV technique was successfully performed in thirty patients, without any FFR-related complications.However, the CON technique failed in three patients,including two who experienced coronary artery spasms (P > 0.05).Conclusions: Compared to the CON technique used for measuring FFR, the new technique reduced the fluoroscopy time and amount of contrast dye used when evaluating complex coronary artery lesions.The new technique did not increase the risk of operation or decrease the success rate.