NAMI-A Preferentially Reacts with Sp1 protein:Understanding Anti-metastasis Effect of the Drug

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户:liujitao0811
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Zinc finger protein Sp1 is associated with tumor development,growth and metastasis.
其他文献
Ruthenium complexes are promising photosensitizers(PSs),but their clinical applications have many limitations.
纳米酶兼具酶和纳米材料的“双重身份”,区别于天然酶和传统模拟酶,纳米酶的高稳定性和催化活性使它在生物医学、生物传感器、免疫分析和癌症治疗等领域的研究受到广泛的关注。
Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux,detoxification by intracellular GSH,and nucleotide excision repair machinery mediated nuc
Nonsense mutations with premature termination codons(PTCs)account for approximately 11%of reported monogenic diseases.
当前,功能性纳米制剂的临床转化存在一个重要问题,其在体内不能降解、难以被肾脏清除。在国内外已有研究中,贵金属纳米粒子(Au 和Pd)作为第一代光热治疗肿瘤的纳米药物得到了广泛的应用,但目前报道的贵金属纳米粒子都是不可降解的。
Metal ions play various important biological functions in proteins including structural maintenance,molecular recognition and catalysis.
利用自下而上的构建方法将纳米尺度的基本单元组装成微米级的三维结构一直是超分子自组装领域的研究热点,DNA 纳米技术的发展为这一研究打开了新的突破口。
2-deoxy-2-fluoroarabinonucleic acid(FANA),which is one type of xeno-nucleic acid(XNA),has been intensively studied in molecular medicine and synthetic biology because of its superior gene-silencing an
临床输血时,当供血者与受血者的血型不匹配时,就会发生溶血性输血反应,严重者会导致受血者死亡。虽然为了满足临床输血的需求,建立了输血库,但用血量逐年增加,尤其是稀有血型更是供不应求。
Though plenty of viral and non-viral methods have been rapidly developed for the delivery of the CRISPR/Cas9 system,the direct delivery of Cas9 ribonucleoproteins(RNPs)into the nucleus for genome edit