Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux,detoxification by intracellular GSH,and nucleotide excision repair machinery mediated nuc
2-deoxy-2-fluoroarabinonucleic acid(FANA),which is one type of xeno-nucleic acid(XNA),has been intensively studied in molecular medicine and synthetic biology because of its superior gene-silencing an
Though plenty of viral and non-viral methods have been rapidly developed for the delivery of the CRISPR/Cas9 system,the direct delivery of Cas9 ribonucleoproteins(RNPs)into the nucleus for genome edit