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Background: Our previous work demonstrated that PTH enhances intravenous (Ⅳ) human mesenchymal stem cells (hMSC) homing to fracture callus.While PTH enhances osteogeneic and chondrogenic differentiation of Ⅳ delivered hMSC during fracture healing, our recently finding indicated that PTH could also significantly increase vascular formation within the new callus.