AIM:Pulmonary arterial hypertension (PAH) is a disease characterized by thickening of pulmonary artery walls,elevated pulmonary vascular resistance,pulmonary vascular thrombotic lesions and right-hear
Rationale:Pulmonary arterial hypertension (PAH) is a malignant disease and the pathological mechanism is unclear.Pulmonary arterial remodeling is a major pathological change of PAH and Pulmonary arter
Aims:Exercise training,a recommended nonpharmacological strategy for hypertensive patients,exerts beneficial effect on blood pressure modulation,but the underlying mechanisms remain elusive.Vascular i
Aims:Vascular insulin resistance contributes to elevated peripheral vascular resistance and subsequent hypertension.Clinical observation has revealed that a low plasma adiponectin concentration is ass
Aim:Junctophilins (JPs) are main membrane-binding proteins that are associated with the functions of junctional membrane complexes (JMC).Small conductance Ca2+ activated K+ channels (SK) profiles the
Background:Our previous studies suggest that MgATP coordinates with calmodulin (CaM) in maintenance of cardiac Cav1.2 channel activity in the inside-out patches via direct interaction with channel.Sin
Our recent study has revealed that calpastatin,an endogenous calpain inhibitor,could not only reprime activity of Cav1.2 Ca2+ channel from run-down in cell-free patches but also directly bind to intra
This study is aimed to investigate the effects of high intracellular Mg2+(Mg2+i)upon the gating-mechanism of L-type calcium channel in guinea-pig ventricular myocytes.By adopting inside-out configurat
Background:Epithelial mesenchymal transition (EMT),which is a crucial event between epithelial and mesenchymal repair,was reported to be possible mechanisms for fibrosis.Our previous work showed that