【摘 要】
：
Peraxisome proliferator-activated receptor δ (PPARδ) has rapidly emerged as a potential target in the battle against dyslipidemia,Type Ⅱ diabetes and obesity,with the therapeutic efficacy in the treat
【机 构】
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Zhejiang Hisun Pharmaceutical Co.Ltd.China
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Peraxisome proliferator-activated receptor δ (PPARδ) has rapidly emerged as a potential target in the battle against dyslipidemia,Type Ⅱ diabetes and obesity,with the therapeutic efficacy in the treatment of cardiovascular disease risk factor.Previous investigation have demonstrated that PPARδ has a significant role in the regulation of lipid and energy homeostasis in major mass peripheral tissues,including macrophages,adipose,heart and especially skeletal muscle tissue.In particular,PPARδ agonist produce dose dependent increases in HDL cholesterol,while lowing LDL cholesterol,fasting triglycerides and insulin specifically by inducing ABCA 1 expression and apoA 1-specific cholesterol effiux in macrophages,intestinal cells and skeletal muscle.Moreover,the PPARδ mediated gene expression in fatty acid absorbtion/transport,lipid catabolism and energy expenditure ameliorated diet induced obesity and insulin resistance.
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