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Doxorubicin is one of the most promising chemotherapeutic agents for the treatment of androgen-independent prostate cancer,non-small-cell lung cancer and locally advanced or metastatic breast cancer.The smart micelles are composed of four key components:(1) a chemotherapeutic agent doxorubicin (DOX); (2) a TAT peptide that can induce endocytosis for cell uptake; (3) a pH sensitive compound SA-SD which is loaded at the hydrophobic core of each micelle; (4) a biodegradable PEG-PE.