【摘 要】
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Viral infection initiates a series of signaling cascades that lead to the transcription of interferons (IFNs), fmally inducing interferon-stimulated genes (
【机 构】
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Institute of Biology and Medical Sciences, Soochow University, Suzhou 215123, China
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Viral infection initiates a series of signaling cascades that lead to the transcription of interferons (IFNs), fmally inducing interferon-stimulated genes (ISGs) to eliminate viruses.Viruses have evolved a variety of strategies to modulate host IFN-mediated immune responses.Herpes simplex virus type 1 (HSV-1) US3, a Ser/Thr kinase conserved in α-herpesviruses, was previously reported to counteract the host innate immunity; however, the molecular mechanism is elusive.
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