heophylline (THO) molecular imprinted composite membranes (MIM) were successfully fabricated by thermal initiated free radical polymerization on the surface of α-Al2O3 ceramic microporous hollow fiber substrate membranes.Molecular imprinted polymerization layer was synthesized by taking theophylline as the template molecule,methacrylic acid (MAA) as the functional monomer,ethylene glycol dimethacrylate (EDMA) as the cross-linker,and 2,2’-azobisisobutyronitrile (AIBN) as the free radical initiator.