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5. Structural insights into product specificities of MLL-family histone methyltransferases

Structural insights into product specificities of MLL-family histone methyltransferases

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：intaaab

【摘 要】

：

　　Methylation of Histone 3 Lysine 4(H3K4)is a critical chemical modification for epigenetic regulation and plays important roles in multiple cellular events.M

【作 者】

：

Yanjing Li Lijie Zhao Jianming Han Yong Chen 

【机 构】

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StateKeyLaboratoryofMolecularBiology,NationalCenterforProteinScienceShanghai,ShanghaiScienceResearch

【出 处】

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中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

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2018年10期

【关键词】

：

Histone methylation methyltransferase MLL complex product specificity 

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论文部分内容阅读

　　Methylation of Histone 3 Lysine 4(H3K4)is a critical chemical modification for epigenetic regulation and plays important roles in multiple cellular events.Mono-methylation of H3K4 is enriched at active enhancers,while trimethylation of H3K4 is usually associated with promoters of actively transcribed genes.

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