Activation of the phosphatidylinositol 3-kinase α(PI3Kα)is commonly observed in human cancer and is critical for tumour progression,which has made PI3Kα an attractive target for anticancer drug discov
Aim To discover novel small molecular inhibitors of sphingomyelin synthase(SMS)as a tool to study the biological function of sphingomyelin synthase and as a lead compound for new preventive and therap
Mammalian thioredoxin reductases(TrxRs),including cytosolic TrxR1,mitochondrial TrxR2,and testisspecific TrxR3,belongs to a homodimeric pyridine nucleotide disulfide oxidoreductases [1] and plays an i