2. 您的位置
3. 首页
4. 会议论文
5. Folate and CPP mediated specific delivery of camptothecin to tumor via pH and reduction dual-sensiti

Folate and CPP mediated specific delivery of camptothecin to tumor via pH and reduction dual-sensiti

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：shadowyin

【摘 要】

：

Camptothecin (CPT) is a naturally occurring alkaloid that shows good antitumor activity in vitro against various tumor cell lines[1].Its potential in clinical uses,however,is hindered by a lack of rea

【作 者】

：

Yanfang Yang Jun Ye Panpan Ma Xueqing Xu Xuejun Xia Yuling Liu 

【机 构】

：

State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Beijing Key Laboratory

【出 处】

：

Fourth Symposium on Innovative Polymers for Controlled Deliv

【发表日期】

：

2016年11期

【关键词】

：

camptothecin delivery polymeric micelles dual-sensitive tumor targeting cell pen 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Camptothecin (CPT) is a naturally occurring alkaloid that shows good antitumor activity in vitro against various tumor cell lines[1].Its potential in clinical uses,however,is hindered by a lack of reaction selectivity,poor water solubility as well as poor cell penetrating ability.

其他文献

Tumor-homotypic reduction-responsive polypeptide nanogels for prostate cancer chemotherapy

Polymeric nanoparticles coated with membranes from various cells,such as erythrocytes,platelets,and cancer cells,exhibit fantastic potential for cancer therapy.Among them,the cancer cell membranes aro

会议

prostate cancercell membranepolypeptide nanogeltargetabilitychemotherapy

Thermo-responsive enhanced emission rare-earth upconversion nanophosphors based on NaLuF4∶yb3+,Er3+

Rare-earth upconversion nanophosphors (UCNPs) have exhibited a great potential as a promising biological luminescent labels for fluorescence imaging and cancer diagnosis[1].Hexagonal ytterbium and erb

会议

UCNPsthermo-responsiveupconversion luminescenceimaging

Magnetic/fluorescent hybrid PLGA nanoparticles for doxorubicin/VEGF siRNA co-delivery and tumor imag

Doxorubicin (Dox) as a traditional chemotherapy drugs,have significant side effects,such as cardiotoxicity,mucositis,myelosuppression,owing to its nonspecific distribution to normal tissues[1].

会议

doxorubicinRNAiCo-DeliveryMR imagingsynergistic antitumor effects

Development of pH sensitive polyacrylic acid grafted hemicellulose hydrogels for colon-specific cont

The water insoluble hemicellulose (wis-AGX) isolated from corncobs,a typical indigestible polysaccharide which is not degradable or disintegrated in the upper gastrointestinal tract,can be used as a c

会议

water insoluble hemicellulosesgraft copolymerizationpH-sensitive hydrogelcolo

Thermosensitive injectable modified chitin hydrogel for cell delivery

Biodegradable injectable hydrogels hold great potential for cell therapy and tissue regeneration because of minimally invasive surgical procedures with the ease of handling and complete filling of the

会议

cell therapyhydroxypropyl chitininjectable hydrogeltemperature responsive

Design of pH-responsive poly(D,L-lactic-co-glycolic acid) nanoparticles to promote immune response

In the quest to treat intracellular infectious diseases and virus infection,nanoparticles (NPs) have been considered to be efficient tools for inducing potent immune responses,specifically cellular im

会议

antigen intracellular rapid releasedendritic cellspH-responsivePLGA nanoparti

Preparation of pH-sensitive nanopolyplexes for efficient light-assisted gene delivery

Gene therapy has played great roles in many disease treatments including cancer therapy.However,inefficient intracellular gene delivery has limited its further application.

会议

gene therapyintracellular deliveryphotochemical internalizationpH-sensitive

Dual micelles loaded gelatin nanofibers and their application in lipopolysaccharide-induced periodon

SP600125 and SB203580 have exhibited a great potential in lipopolysaccharide (LPS)-induced periodontal therapy.However,due to their poor water solubility,the burst release has remained to be the major

会议

micellesgelatin nanofibersdrug deliveryelectrospinning

Traceable nanoparticle with temporally release ability to control neural stem cell differentiation f

Alzheimers disease (AD) is the most prevalent age-related neurodegenerative disorder.The predominant pathologies of AD are gliosis and widespread neuronal loss.Although neural stem cells (NSCs) could

会议

Alzheimer's diseaseneural stem cellsRNA interferencemagnetic resonance i

Nanoplatform containing MMPs-sensitive peptide-PEG conjugate and tissue-penetrating moiety for enhan

Nanovesicles have proven to be promising drug-delivery systems owing to their good biocompatibility,sustained-release potential and lower immunogenicity[1].

会议

nanoplatformMMPs-sensitivepeptide-PEG conjugatetumor-penetratingdrug deliver