【摘 要】
：
The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel chemical entities of increased potency [1-5].Previous investigations in
【机 构】
：
Department of Medicinal Chemistry,Key Laboratory of Chemical Biology of Natural Products(Ministry of
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel chemical entities of increased potency [1-5].Previous investigations in our laboratories resulted in the discovery of several novel series of arylazolylthioacetanilides as potent NNRTIs[6-14].In this study,based on the structure-based bioisosterism strategy,novel 1,2,4-triazin-6-ylthioacetamide derivatives were designed,synthesized and evaluated for their anti-HIV activity in MT-4 cells for the first time.
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