【摘 要】
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Background: Rheumatoid arthritis (RA) is an autoimmune inflammatory polyarthritis that often leads to joint destruction, deformity, and loss of function.The immune system has been the primary target o
【机 构】
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Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland,
【出 处】
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第七届国际骨质疏松及骨矿盐疾病学术会议
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Background: Rheumatoid arthritis (RA) is an autoimmune inflammatory polyarthritis that often leads to joint destruction, deformity, and loss of function.The immune system has been the primary target of disease modifying anti-rheumatic drugs.However, the joint destruction is not effectively halted with these treatments.
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大量研究表明,超生理量的类固醇激素及其类似物对骨骼系统的发育、生长与细胞代谢有明显不利影响.在成人,糖皮质激素所致的骨质疏松症(Glucocorticoidinduced osteoporosis,GIOP)是临床上较常见的激素治疗并发症之一,是临床上最常见的继发性骨质疏松症.在骨质疏松症中其发病率仅次于绝经后骨质疏松症(Postmenopausal osteoporosis)及老年性骨质疏松症(
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