A nationwide multicenter retrospective study from 1999 to 2008 was performed in China.A total of 135 (3.2%) invasive lobular carcinoma (ILC) cases were compared with 3471(82.4%) invasive duetal carcinoma (IDC) by clinicopathological features.The proportion of Luminal A type of ILC is significantly larger than that of IDC.ILC is a distinct entity and treatment should be individualized.Background:To analyze the clinicopathological features of invasive lobular carcinoma (ILC) and compare them with invasive ductal carcinoma (IDC),hoping to find the fact of ILC in China and assist the decision makers with proper individualized treatment.Patients and Methods:A nationwide multicenter retrospective study was performed.4211primary breast cancer cases were randomly selected from 1999 to 2008 in 7 regions of China.ILC cases were compared with IDC by clinicopathological features and molecular subtypes.Results:A total of 135 (3.2%) ILC and 3471 (82.4%) IDC cases were included for analysis.The age,tumor size,menopausal state,family history,nodal status and stage of ILC were similar to that of IDC.ILC was more likely to be positive for estrogen receptor(ER)(65.5% vs.57.7%) and progesterone receptor(PR)(64.7% vs.58.5 %),and less likely to overexpress human epidermal growth factor receptor-2 (HER2)(17.3% vs.23.6%).Even though these differences are not significant, the proportion of Luminal A type of ILC is significantly larger than that of IDC (54.8% vs.42.7 %; P<0.05).Conclusion: ILC has a larger proportion of Luminal A type compared with IDC.Larger sample size study for better known of molecular subtypes of ILC is needed in future to individualize the treatment decision.