The CRISPR/Cas9 system is a novel genome editing technology which has been successfully used to inhibit HBV replication.Here we described a novel gRNA-micro
The covalently closed circular(CCC)DNA of hepatitis B virus(HBV)is the sole transcriptional template able to produce all viral RNAs and is essential for est
Following the entry of hepatitis B virus(HBV)into hepatocytes via NTCP receptor,the viral relaxed circular(rc)DNA genome is transported into the nucleus and
The hemorrhagic fever with renal syndrome(HFRS)as a zoonotic disease threatens public health and its incidence increased sharply for present years in southe