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5. RPL6 directly binds to histone H2A and suppresses H2Aubiquitylation in DNA damage response and repai

RPL6 directly binds to histone H2A and suppresses H2Aubiquitylation in DNA damage response and repai

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：Hmilts

【摘 要】

：

Ubiquitylation has emerged as a critically important mechanism for spatiotemporal regulationof DNA damage response and repair.H2A/H2AX ubiquitylation surroundin

【作 者】

：

李亭亭 姬亚朋 郑晓峰 

【机 构】

：

北京大学生命科学学院

【出 处】

：

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

：

2014年8期

【关键词】

：

H2A ubiquitylation RPL6 DNA damage response 

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Ubiquitylation has emerged as a critically important mechanism for spatiotemporal regulationof DNA damage response and repair.H2A/H2AX ubiquitylation surrounding thedouble-strand breaks, a vital step in this highly orchestrated process,is initiated by E3 ligaseRNF8 and RNF168.

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