【摘 要】
：
Hippocampal long-term potentiation (LTP) is believed to be the mechanism underlying certain types of memory,which is exquisitely sensitive to stress.In the present study,we introduced a naïve fem
【机 构】
：
Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, China
【出 处】
：
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Hippocampal long-term potentiation (LTP) is believed to be the mechanism underlying certain types of memory,which is exquisitely sensitive to stress.In the present study,we introduced a naïve female rat to a stressed male rat that just experienced contextual fear conditioning,for 24 hours in home cage where they showed sexual behaviors.Remarkably,these male rats exhibited much lower contextual fear than those without female rats,and their impaired LTP of the field excitatory postsynaptic potentials in hippocampal CA1 was restored.In marked contrast,when we introduced a naïve male rat to a stressed male rat that was trained in contextual fear conditioning,the male rats still showed high levels of contextual fear and the impaired LTP.In addition,the effects of female both on behavior and electrophysiology were prevented by the dopamine D1/D5 receptor antagonist SCH 23390.These novel findings suggest that heterosexual contact decreases contextual fear and prevents the impairment of hippocampal LTP,thereby providing potential explanation why heterosexual contacts modulate mood and promote work efficacy in humans.
其他文献
Up to now,many neural coding theories have been proposed,such as rate code,temporal code,population code,etc.However,many of them contradict with each other.We think that theoretical consideration is
For a long time,the ability of neurons to respond to an electrical shock with an action potential is a property referred to as an excitation.The threshold voltage or firing number is as an index measu
The never fiber has been defined as a long neuronal process,which works as a relatively sample relay line between neurons,insuring the conduction of information from the cell body to the nerve termina
With help of nonlinear science,neural firing patterns have attracted more and more attention in the researches on neural encoding mechanism since 1980.Periodicity and chaos,the behaviors of nonlinear
Single excitable cells are capable of various rhythmic firing.Some neurons,especially the sensory neurons,encode the external stimulus into the temporal patterns of firing series.The dynamics as well
Histaminergic neurons reside in the tuberomammillary nucleus of the posterior hypothalamus where histamine is synthesized by the specific enzyme,histidine decarboxylase (HDC),and send widespread proje
Histaminergic output from the tuberomammillary nucleus (TMN) is considered to play a crucial role in mediating arousal.Under physiological conditions,the extracellular histamine levels in the preoptic
The top-down descending roles from higher cortical areas to lower areas is a big unsolved problem in systems neuroscience.In the visual system,the dorsal stream and the ventral stream are two the majo
TTX-sensitive (TTX-S) Navl.3 sodium channel is barely detectable in adult DRG or spinal cord.After nerve injury,however,the channel is up-regulated dramatically,which may contribute to neuropathic pai
Glial cells in the central nervous system received lots of attention for their possible roles in the creation and maintenance of chronic pain.Satellite cells,one of the major types of glial cells in t