【摘 要】
：
Vancomycin group compounds belong to the glycopeptide class of antibiotics, which are synthesized by non-ribosomal peptide synthetase (NRPS), produced exclusively by actinomycetes.Vancomycin is clinic
【出 处】
：
The 13th International Conference on Culture Collections(ICC
论文部分内容阅读
Vancomycin group compounds belong to the glycopeptide class of antibiotics, which are synthesized by non-ribosomal peptide synthetase (NRPS), produced exclusively by actinomycetes.Vancomycin is clinically used as the last-line therapy against intrinsically multi-drug resistant Enterococci, methicillin-resistant Staphylococcus aureus (MRSA), and methicillin-resistant Staphylococcus epidermidis (MRSE), although their significant nephrotoxicity and ototoxicity.However, the emergence of acquired vancomycin resistance among Enterococci has been very common, which requires to discovery novel vancomycin group antibiotics with higher antibacterial activity and lower toxicity.
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