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Background To investigate whether glycation level of apoprotein (apo)A-I is associated with coronary artery disease (CAD) and plaque progression in patients with type 2 diabetes.Methods Among 375 consecutive type 2 diabetic patients undergoing quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS),82 patients with nonsignificant stenosis (luminal diameter narrowing <30% (group Ⅰ)) and 190 patients with significant CAD (luminal diameter stenosis ≥70% (group Ⅱ)) were included for analysis of apoA-I glycation level and serum activity of lecithin: cholesterol acyltransferase (LCAT).The control group had 136 healthy subjects.At the 1-year follow-up,angiography and IVUS were repeated mainly in group Ⅱ patients for plaque progression assessment.