Computational biomechanics is the study of biology at the organ and tissue level using computer simulation technologies based on mathematical and numerical models.With the rapid development of HPC over the past decades,the possibilities of utilizing these simulation technologies in real life medical practices have dramatically increased.The mathematical modeling of many biological systems,such as blood flows,arteries,and heart deformation take the form of partial differential equations.The focus of this minisymposium is on efficient numerical methods and high performance software for solving partial differential equations arising in the study of biofluid dynamics and biostructural mechanics.