PD-L1 dependent and independent pathways for driving CD8+ T cell suppression and exhaustion during c

来源 :第四届中德免疫学研讨会 | 被引量 : 0次 | 上传用户：ffdsfdsadsfafdsa

【摘要】

：

Metastasis is the primary cause of cancer related mortality.Immunotherapy is becoming the most promising new modality for cancer treatment, which can lead to co

【作者】

：

F.Xiao-Feng Qin

【机构】

：

CenterforSystemsMedicine,InstituteofBasicMedicalSciences,ChineseAcademyofMedicalSciences&PekingUnion

【出处】

：

第四届中德免疫学研讨会

【发表日期】

：

2015年11期

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Metastasis is the primary cause of cancer related mortality.Immunotherapy is becoming the most promising new modality for cancer treatment, which can lead to complete and long-lasting treatment response, central for preventing cancer metastasis and disease relapse.Clinical trials with monoclonal antibodies to immune checkpoint inhibitory receptor PD-1 and its ligand PD-L1 have shown remarkable clinical response in melanoma, renal carcinoma and non-small-cell lung cancer patients with unprecedented survival benefit.

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PD-L1 dependent and independent pathways for driving CD8+ T cell suppression and exhaustion during c

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