Background: This study investigated and quantified the dosimetric impact of the distance from the tumor to the spinal cord and fractionation schemes for patients who received stereotactic body radiation therapy (SBRT) and hypofractionated simultaneous integrated boost (HF-SIB).Material/Methods: Six modified planning target volumes (PTVs) for 5 patients with spinal metastases were created by artificial uniform extension in the region of PTV adjacent spinal cord with a specified minimum tumor to cord distance (0-5 mm).The prescription dose (biologic equivalent dose, BED) was 70 Gy in different fractionation schemes (1, 3, 5, and 10 fractions).For PTV V100, Dmin, D98D95and D1spinal cord dose, conformity index (CI), V30 were measured and compared.Results: PTV-to-cord distance influenced PTV V100Dmin D98and D95and fractionation schemes influenced Dmin and D98with a significant difference.Distances of ≥2 mm, ≥1 mm, ≥1 mm, and ≥0 mm from PTVto spinal cord meet dose requirements in 1, 3, 5, and 10 fractionations, respectively.Spinal cord dose, CI, and V30 were not impacted by PTV-to-cord distance and fractionation schemes.Conclusions: Target volume coverage, Dmin, D98and D95 were directly correlated with distance from the spinal cord for spine SBRT and HF-SIB.Based on our study, ≥2 mm, ≥1 mm, ≥1 mm, and ≥0 mm distance from PTV to spinal cord meets dose requirements in 1, 3, 5 and 10 fractionations, respectively.