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  5. Dual-peptide-decorated PEGylated poly(2-(dimethylamino) ethyl methacrylate)/DNA complexes targeting

Dual-peptide-decorated PEGylated poly(2-(dimethylamino) ethyl methacrylate)/DNA complexes targeting

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：yiyiyaya13575
【摘 要】
：
　　Purpose To establish and characterize a gene delivery system based on PEGylated poly (2-(dimethylamino)ethyl methacrylate) (PEG-PDMAEMA) decorated with phag
【作 者】
：
XiaoyaoZheng;XiaoyingPang;PengYang;YueWei;QizhiZhang; 
【机 构】
：
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, People's Repub
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年期
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　　Purpose To establish and characterize a gene delivery system based on PEGylated poly (2-(dimethylamino)ethyl methacrylate) (PEG-PDMAEMA) decorated with phage-displayed TGN peptide (targeting to the blood-brain barrier) and QSH peptide (targeting to Aβ42) to achieve enhanced and precise targeted delivery to amyloid plaques in the brains, which were the hallmark of Alzheimer's disease (AD).
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