Objectives To evaluate the risk and protective factors for UGI bleeding in a large cohort of PCI patients.Methods A case-control study evaluating UGI bleeding within 7 days following PCI for stable angina and acute coronary syndromes, at Guizhou Provincial Hospital between 2008 and 2011.Cases (n =27) were identified and outcomes assessed using analysis of data about PCI patients in Discharge Registry Department, and a detailed review of medical notes for each case and four matched controls (n =108).