Genome-wide DNA methylation analysis reveals activation of Wnt signaling pathway in peripheral T-cel

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户：houzi7731

【摘要】

：

【作者】

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Xia Zhao Wei Zhang Weili Zhao

【机构】

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State Key Laboratory of Medical Genomics,Shanghai Institute of Hematology,Shanghai Rui Jin Hospital

【出处】

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The 35th World Congress of the International Society of Hema

【发表日期】

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2014年5期

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Background:Peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS)constitutes a heterogeneous group of T-cell malignancy.Resistant to conventional chemotherapy,patients usually have poor disease outcome.Epigenetic silencing of tumor suppressor genes is a major event in the pathogenesis of hematologic malignancies.

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Genome-wide DNA methylation analysis reveals activation of Wnt signaling pathway in peripheral T-cel

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