Xanthotoxol ameliorates the ischemia/reperfusion-induced impairment of long-term potentiation induct

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户:honest
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim: Cerebral ischemia can impair the induction of activity-dependent longterm potentiation (LTP) in the hippocampus.Here, we investigated the effect of xanthotoxol on the induction of activity-dependent LTP and the expression of NR2A and NR2B subunit NMDA receptor in the hippocampal CA1 region after focal cerebral ischemia/reperfusion injury.
其他文献
Aim: Parkinsons disease is one of the most common neurodegenerative diseases.Mutation in human PTEN induced protein kinase 1 (PINK1) gene is responsible for the second most common form of recessive Pa
Aim: An augmented brain renin angiotensin system (RAS) activity has recently been shown to be involved in pathophysiology of Alzheimers disease.Drugs that act by manipulating RAS such as ACE inNbitom
会议
Huntingtons disease (HD) is an autosomal dominant hereditary disease caused by a trinucleotide repeat mutation in the huntingtin gene that results in an increased number of glutamine residues in the N
Aim: Metallothioneins are ubiquitous low molecular weight, cysteine-rich and metal binding proteins in mammals.The major isoforms in CNS are MT-Ⅰ and-Ⅱ which localize mainly in astrocytes.Recently sig
Aim: To observe the effects of extract from Semen Ziziphus spinosa and Fructus Schisandrae Chinensis on the content of amino acid neurotransmitter in the hypothalamus of insomnia rats caused by DL-P-c
Aim: Discovery of new antidepressants from traditional Chinese medicine is one of the promising field for the treatment of the major depressive disorders.Furostanol saponins (termed B3 in this study),
Aim: There are increasingly reports of beneficial effects of exercise on depressive disorder and cognitive impairment in humans.Cognitive impairment is one of the main symptoms in depression.However,
Aim: To investigate whether 20(R)-ginsenoside Rg3 (20(R)-Rg3) exhibits neuroprotective effect against delayed neuronal injury induced by transient cerebral ischemia and reperfusion in rats.Methods: Ad
Aim: An attempt has been made to explore the neuroprotective and antitremor effect of baicalein on neurons against experimental Parkinsonism.Methods: In in vitro experiments, we found that baicalein c
Aim: To evaluate the neuroprotective efficacy of Chinese toon on cerebral ischemic reperfusion model of rats and explored the underlying mechanisms.Methods: Rats were subjected to occlusion of the mid