【摘 要】
：
界面核酸分子的结构与动力学是决定核酸药物稳定性与功效的关键.本实验室研发了一套偏振分辨和频振动光谱(SFG-VS)系统用于生物界面的原位、实时、免标记的检测.利用该光
【机 构】
：
江汉大学交叉学科研究院巴黎第十一大学分子科学研究所
【出 处】
：
中国化学会生物物理化学专业委员会第四届全国生物物理化学会议
论文部分内容阅读
界面核酸分子的结构与动力学是决定核酸药物稳定性与功效的关键.本实验室研发了一套偏振分辨和频振动光谱(SFG-VS)系统用于生物界面的原位、实时、免标记的检测.利用该光谱检测系统,我们对核酸分子在层状正电荷DMTAP 磷脂双层膜上的分子构相与吸附动力学进行了研究.PO2-波段,OH/NH 波段和“指纹区”波段的光谱数据显示,核酸分子的吸附在375 nM(ρ ≈ 3.75)达到饱和,取向角也趋于稳定.
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