【摘 要】
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Lessons from the covalent capture of small-molecule self-assemblies(molecular weight of monomer < 500.0)are applied to grow a generic cross-linked small-molecule micelle based drug delivery system(CSM
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Lessons from the covalent capture of small-molecule self-assemblies(molecular weight of monomer < 500.0)are applied to grow a generic cross-linked small-molecule micelle based drug delivery system(CSM-DDS),which represents significant advantages over the popular polymeric micelle based drug delivery systems on drug loading,stability,monomer purity and cost of preparation.A proof-of-concept CSM-DDS constructed by one-step synthesized amphiphile 1 with anti-cancer drug gemcitabine confirms the feasibility of the new strategy by its high drug loading content(up to 58%),robust stability,superior predictable biosafety,facile functionalization and remarkable anticancer activity both in vitro and in vivo.
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