【摘 要】
：
Background Cettriaxone/sulbactam(4∶1)is a novel β-lactam/β-lactamase-inhibitor combination injection.A clinical study was designed to evaluate its efficacy and safety in the treatment of respiratory a
【机 构】
：
Key Laboratory of Infectious and Parasitic Diseases in Chongqing,Infectious DiseaseDepartment,First
【出 处】
：
中国药理学会第十一届全国化疗药理学术研讨会
论文部分内容阅读
Background Cettriaxone/sulbactam(4∶1)is a novel β-lactam/β-lactamase-inhibitor combination injection.A clinical study was designed to evaluate its efficacy and safety in the treatment of respiratory and urinary infections caused by ceftriaxone-resistant bacteria comparing with cefoperazone/sulbactam(2∶1)on cefoperazone-resistant bacteria.Methods A total of 285 patients with respiratory or urinary tract infections were enrolled into this multicenter,open-label,randomized controlled clinical study,and the bacteria isolated from whom were either ceftriaxone-resistant or cefoperzaone-resistant.Two hundred fifty three patients completed the trial and 263 were enrolled into the ITT analysis.
其他文献
目的 研究中国健康志愿者口服左氧氟沙星(可乐必妥)单次给药以及每日1次连续给药7d的药动学特征,为该制剂在中国人群中临床合理给药提供依据.方法 ①9名受试者随机交叉单次口服200、500或700 mg的单个剂量的左氧氟沙星片；②9名受试者接受多剂给药,即每日单次口服左氧氟沙星500mg,连续7d.血、尿标本中左氧氟沙星药物浓度均用高效液相色谱法测定.结果 ①单剂药动学：受试者分别口服左氧氟沙星20
Background The qacA/B genes are found in Staphylococcus aureus and confer resistance to various antiseptics and disinfectants.Herein,the prevalence of the qacA/B genes in methicillin-resistant S.aureu
目的 本课题采用A549及其耐顺铂细胞株A549/CP为研究对象,探讨佛波酯能否增强肺腺癌细胞对顺铂的敏感性,并进一步研究其增敏机制.方法 采用MTT比色法检测佛波酯和顺铂分别单用及联合对肿瘤细胞增殖的影响,评价佛波酯对顺铂的增敏作用的.用石墨炉原子吸收法检测佛波酯作用前后肿瘤细胞内铂离子浓度的变化.以Na+,K+-ATP酶活性检测试剂盒和Western blot法检测佛波酯对两种肿瘤细胞细胞Na
OBJECTIVES To investigate the molecular epidemiology of genes that confer resistance to fluoroquinolones and extended spectrum β-lactams in non-typhoidal Salmonella(NTS)from food producing animals in
目的 了解汕头市2010年性病科念珠菌菌种分布及菌株对五种常用抗真菌药物的耐药性.方法 对就诊患者进行念珠菌，纸片法测定念珠菌对抗生素药物敏感性.结果 574例标本共培养159株念珠菌(27.70％)，其中，白念珠菌141株(88.67％)，光滑念珠菌11株(6.92％)，热带念珠菌5株(3.14％)，克柔念珠菌2株(1.26％).药敏试验显示：白念殊菌对特比萘芬有较高的耐药率，其次是伊曲康唑、氟
目的 了解汕头大学医学院附属第一医院分离的92株MRSA的耐药情况及其SCCmec基因型。方法 琼脂稀释法测定16种抗菌药物对MRSA的最低抑菌浓度(MIC)多重PCR扩增检测MRSA的SCCmec分子分型。结果 92株MRSA对实验中所有β内酰胺类抗生素的耐药率均在80％以上。绝大部分菌株对庆大霉素、红霉素、氟喹诺酮类也不敏感。超过半数的MRSA菌株对利福平保持敏感，对氯霉素，多西环素及米诺环素
目的 初步观察评价扶正固本(黄芪、女贞子等)、软坚散结(半夏、夏枯草等)、化痰祛湿(白术、半夏等)、益气养血(党参、黄芪等)、活血化瘀(丹参、川芎等)、清热解毒(白花蛇舌草、半枝莲等)6种治则方剂对肿瘤化疗药物表阿霉素抗肿瘤活性的增效作用.方法 血清药理学通法制备含药血清.微孔培养板培养A549肺癌细胞,MCF-7乳腺癌细胞以及BGC-823胃癌细胞,观察6种含药血清对表霉素肿瘤抑制活性的影响,M
Gene therapy has been considered to be the promising and accomplishing approach to counter persistent HBV infection and primary hepatocellular carcinoma(HCC).Replication-defective adenoviruses were on
目的 探讨阿奇霉素对OVA致敏大鼠Th1/Th2失衡及转化生长因子-β(TGF-β)表达的影响.方法 SD大鼠40只,随机分为生理盐水组、OVA模型组、地塞米松(0.5 mg/kg)组以及阿奇霉素(25 mg/kg)治疗组,每组10只.利用卵白蛋白(Ovalbumin,OVA)/A1(OH)3致敏与OVA雾化吸入激发建立大鼠过敏性气道炎症模型,收集肺泡灌洗液(BALF)进行白细胞分类计数；采用EL