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抗心律失常药物的主要作用靶点是对心肌动作电位的形成有重要贡献的离子通道。心肌内向整流钾通道(IK1 通道)是维持和稳定心肌静息电位的最重要的离子通道，也参与动作电位的形成。因此干预IK1 通道对心肌的兴奋性和心律失常的发生将产生重要的作用。
Zacopride通过选择性激动IK1通道发挥抗心律失常和抗心室重构作用
【摘 要】
：
抗心律失常药物的主要作用靶点是对心肌动作电位的形成有重要贡献的离子通道。心肌内向整流钾通道(IK1 通道)是维持和稳定心肌静息电位的最重要的离子通道，也参与动作电位
【机 构】
：
山西医科大学山西妇幼保健院功能实验室山西大医院心内科北京协和医院基础学院生理室
【出 处】
：
中国生理学会第24届全国会员代表大会暨生理学学术大会
【发表日期】
：
2014年10期
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