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Poly(A)-specific ribonuclease (PARN), a deadenylase with the unique properties of extremelyhigh catalytic efficiency and cap-dependent processivity, participates in diversephysiological processes by regulating the processing, translation efficiency and decay ofmRNA through deadenylation.PARN is a multi-domain protein containing three RNAbindingdomains (the nuclease, R3H and RRM domains) and a C-terminal domain.Thestructural basis of its high processivity remains unclear.