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目的比较益气活血解毒方和血府逐瘀胶囊抑制再狭窄中细胞外基质的作用特点。方法用电刺激兔颈总动脉,喂饲高脂饲料,再用球囊原位扩张造成动脉粥样硬化再狭窄模型,病理取材,HE、Masson染色及平滑肌细胞肌动蛋白α-SM-actin免疫组化分析和图像分析。结果益气活血解毒方能显著减少内膜增生,尤其是降低血管局部胶原含量的作用最显著。而血府逐瘀胶囊可明显降低血清转化生长因子(TGF-β)的含量,也可减少血管局部的胶原含量。同时两组对内膜平滑肌细胞数均无影响。结论两种中医治则治法对再狭窄均有一定程度的抑制作用,但二者作用的病理环节有所不同。
Objective To compare the effects of Yiqi Huoxue Jiedu Decoction and Xuefu Zhuyu Capsule on the extracellular matrix of restenosis. Methods Electrical stimulation of common carotid arteries in rabbits was used to feed high-fat diets. The model of atherosclerotic restenosis was induced by balloon in-situ expansion. Histopathology, HE, Masson staining, and actin-α-SM-actin immunization of smooth muscle cells were used to immunize rabbits. Group analysis and image analysis. Results Yiqihuoxuejiedu can significantly reduce intimal hyperplasia, especially the effect of reducing local collagen content in blood vessels. The Xuefu Zhuyu capsule can significantly reduce the serum transforming growth factor (TGF-β) content, but also can reduce the local collagen collagen content. At the same time, both groups had no effect on the number of intimal smooth muscle cells. Conclusion Both TCM treatment methods have a certain degree of inhibition on restenosis, but the pathological aspects of the two are different.