Targeting the IL-1B/EHD1/TUBB3 axis overcomes resistance to EGFR inhibitors in non-small-cell lung c

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户:jonsh123
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  Objective Epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(EGFRTKIs)significantly prolongs survival time for patients with activating EGFR mutations in non-small cell lung cancer(NSCLC).
其他文献
Objective Gastric cancer(GC)is the second most commonly diagnosed cancer among men and the third among women,and it is the second leading cause of cancer-related deaths worldwide.
目的 顺铂是胃癌化学治疗的一线药物.先天性和获得性的抵抗极大地影响了患者的预后.microRNA(miRNA)可通过同时调控多条信号通路及肿瘤恶性生物学行为,从而影响顺铂的细胞毒性.因此,探索基于miRNA 的新治疗策略对于GC 来说是非常紧迫的.
会议
Objective Accumulating studies have reported the aberrant expression of SLC5A1 is a negative prognostic factor to various cancer patients.
Objective Background: Breast cancer is the most commonly diagnosed female cancer and the 6th leading cause of cancer-related death in Chinese women.
Objective Colorectal cancer is one of the most common cancer worldwide.The detailed molecular mechanisms related to colorectal cancer tumorigenesis and progression remain poorly understood.
Objective Emerging evidence has indicated that deregulation of long non-coding RNAs(lncRNAs)can contribute to the progression of human cancers,including hepatocellular carcinoma(HCC).
Objective Prostate cancer accounts for 19%of estimated new cancer cases in men and is the third primary cause of male cancer-related mortality after lung cancer and colon cancer in United States.
目的 目的:探讨Skp2 与Sp1 在膀胱尿路上皮癌中的表达及临床意义。方法 方法:采用免疫组织化学PV-6000 法检测69 例膀胱癌和20 例正常膀胱粘膜组织中Skp2 及Sp1 蛋白表达,分析Skp2 及Sp1 在膀胱尿路上皮癌的不同临床分期、病理分级中的表达及其临床意义。
Objective Osteosarcoma is the most common primary malignant tumor of bone that most commonly affects children,adolescents,and young adults,with a global incidence of approximately one to three cases p
目的 本研究旨在以circXPO1 为研究对象,先进行circXPO1 的验证和生物学特性实验,分析其在肺腺癌中的表达特征,探讨circXPO1 的临床相关性和预后价值;然后通过体内体外实验进一步研究其生物学功能;最后借助生物素标记的pulldown 实验与RNA 免疫共沉淀实验的相互印证,找到与circXPO1 特异性结合的蛋白,深入研究circXPO1 在肺腺癌中发挥调控作用的机制,为肺腺癌的