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A series of aryl-2H-pyrazole derivatives were synthesized and evaluated for inhibitory activity against xanthine oxidase in vitro as potent xanthine oxidase inhibitors.Among them,2 aryl-2H-pyrazole derivatives showed significant inhibitory activities against xanthine oxidase.Compound 19 emerged as the most potent xanthine oxidase inhibitor(IC50=9.8 μM)in comparison with allopurinol(IC50= 9,5 μM).The docking study revealed that compound 19 might have strong interactions with the active site of xanthine oxidase.This compound is thus a new candidate for further development for the treatment of gout.