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5. Generation of transgenic mice with megabase-sized human DNA

Generation of transgenic mice with megabase-sized human DNA

来源 :The 11th transgenic Technology Meeting ISTT2013 ( 第十一届国际转基因技 | 被引量 : 0次 | 上传用户：monishibi

【摘 要】

：

Introducing human genes into mice is of importance for addressing fundamental questions related to the function of human genes or for therapeutic use.For proper

【作 者】

：

Liangping Li Thomas Blankenstein 

【机 构】

：

MolecularImmunologyandGeneTherapy,MaxDelbruckCenterforMolecularMedicine,Berlin-Buch,Germany;Zhongsha

【出 处】

：

The 11th transgenic Technology Meeting ISTT2013 ( 第十一届国际转基因技

【发表日期】

：

2013年2期

【关键词】

：

large gene loci yeast artificial chromosome T cell receptor 

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论文部分内容阅读

Introducing human genes into mice is of importance for addressing fundamental questions related to the function of human genes or for therapeutic use.For proper gene regulation or in case of multi-gene families, often large, megabase-sized DNA fragments have to be used.

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