论文部分内容阅读
At the initial work, we have succeeded in resolving the problem of how to prepare the optimized Solid-in-Oil (S/O) nano-suspension-type TDDS containing sparingly soluble methotrexate through basic amino acid ion-pair formations.And the skin permeation enhancement potential of prepared nano-carrier was evaluated based on in vitro percutaneous absorption studies using the classic Franz diffusion cell and Yucatan micropig (YMP) skin.